Recent years have seen a significant increase in the number of counterfeit drugs available on the world market, with global channels such as the internet making it far easier for fraudsters to sell their wares. The cost to manufacturers is massive, not only in terms of the direct sales lost, but also in terms of the impact on brand trust and loyalty. The debate over ePedigree legislation in the US has also raised many questions regarding if and when European manufacturers will be legally required to maintain a chain of custody using a specific technology and if so, which of these technologies will win out – RFID or 2D bar coding?